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Birth Control: Getting Started and Best Practices

What's the difference between a combination pill and a progestin-only pill (mini-pill)?

Last updated on September 1, 2020

Combination birth control pills contain a combination of two hormones, estrogen and progestin, while progestin-only pills contain (you guessed it!) progestin only. Progestin-only pills are also referred to as the mini-pill or POP.

Your doctor might recommend a progestin-only pill to you if you have certain health factors that make taking a combination pill risky.  For example, a progestin-only pill might be better for you if you are a smoker over 35 years of age, if you are breastfeeding, or if you have high blood pressure, migraines with aura, or a history of blood clots or stroke.

Important differences to take into account between progestin-only pills and combination pills:

  • Progestin-only pills must be taken at the same time every day to maintain pregnancy protection - their effectiveness decreases more drastically than that of combination-pills if taken irregularly. Put another way, while both types of pills are quite effective if taken regularly, combination pills are more forgiving if you miss or forget a pill.
  • There are no placebos in a progestin-only pill pack; just 28 progestin-only pills that are taken continuously. Most women still have a period while on the progestin-only pill, but many report that the pill makes it lighter.
  • Some women experience more mid-cycle spotting while on the progestin-only pill, but this often decreases after a few weeks or months of use.
  • Many experience fewer side effects from the progestin-only pill than from combination pills.

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